Araboncology

Natoinal Saudi Campaign for Breast Cancer

noreply@blogger.com (Gulfoncology) — Mon, 15 Mar 2010 15:44:00 +0000

تدشن مديرية الشؤون الصحية في الأحساء، مساء غد الاثنين، ملتقى إعلاميا نسائيا عن «الحملة الوطنية لمكافحة السرطان»، في فندق «الأحساء انتركونتيننتال» برعاية حرم محافظ الأحساء الأميرة العنود بنت محمد آل الشيخ. وأوضح مدير «صحة الأحساء» رئيس اللجنة العليا المنظمة للحملة حسين الرويلي، أن «لجنة إدارة الإعلام والتوعية الصحية أتمت الإعدادات اللازمة لدعم الجهود المبذولة في سبيل الوصول إلى مستوى عال من الوعي الصحي، للحد من الإصابات بالأورام السرطانية لدى المجتمع». ويستضيف اللقاء رئيسة قسم الأشعة التخصصية في مستشفى الملك فهد الجامعي في الخبر الدكتورة فاطمة الملحم، واستشارية الطب النفسي الدكتورة فاطمة المحيش، واختصاصية التغذية العلاجية بُشرى بوعلي، واختصاصية العلاج الطبيعي منى طلعت، واختصاصية الصيدلة سلامة العمران. كما ستشارك جهات حكومية عدة، منها إدارة التربية والتعليم (بنات)، والتعليم العالي، والغرفة التجارية، والمعاهد والكليات الصحية والتربوية، والجمعيات الخيرية، وشخصيات نسائية. وتتضمن فعاليات الملتقى عيادة الكشف المبكر عن أورام الثدي، ومعرضاً توعويا،ً يسعى المشاركون من خلاله التأكيد على مكافحة هذا المرض.

Venous thromboembolism risk stratification in medically-ill hospitalized cancer patients. A comprehensive cancer center experience

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 01:02:00 +0000

Pubmed

Cancer and its treatment are recognized risk factors for VTE. Compliance rate with published VTE prophylaxis guidelines is low. Decision on when to offer prophylaxis for hospitalized cancer patients is difficult to make. This paper describes current clinical practice in offering VTE prophylaxis to hospitalized cancer patients. Prophylaxis rate and rate of VTE will be correlated with the risk level. We prospectively followed all consecutive adult cancer patients admitted to medical units over a 5-month period. Caprini risk assessment model, with some modifications, was utilized to determine risk of VTE. Six hundred and six patients (51% males, median age 52 years, range 18-91) were included. Reasons for admission included infections (25%), chemotherapy (22%) and palliative care (10%). In addition to cancer, the most frequently encountered risk factors for VTE were: Immobilization (35%), age > 60 years (31%) and body mass index > 30 in (20%). Patients were grouped according to their total risk score: low (9%), moderate (44%) and high risk (47%). VTE prophylaxis rate was 55.1% for the whole study group. Following discharge, patients were followed for 60 days. The incidence of VTE was 3.4% in the moderate and 4.2% in the high risk groups, while none in the low risk group developed VTE. Many additional risk factors for VTE are usually encountered in hospitalized cancer patients. Cancer alone may not be an enough reason for VTE prophylaxis. Risk assessment model able to stratify patients into different risk categories will simplify decision making and enhance VTE prophylaxis rate.

Knowledge and beliefs of Jordanians toward colorectal cancer screening

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 01:00:00 +0000

Pubmed

BACKGROUND: Colorectal cancer is a significant health problem; it is the most common malignancy of the gastrointestinal tract. Colorectal cancer is closely related to the clinical and pathological stage of the disease at diagnosis, which can be detected early through screening tests. OBJECTIVE: This descriptive cross-sectional study was conducted to investigate the knowledge and beliefs of Jordanians toward colorectal cancer (CRC) screening using the Health Belief Model. METHODS: One hundred sixty participants, 50 years and older, were identified in the outpatient clinics at the 2 largest Jordanian hospitals located in the north of the country; the King Abdullah University Hospital and the Princess Basma Hospital. RESULTS: Data analyses revealed that most participants are not well informed about CRC and screening. Less than half perceived themselves as susceptible to developing CRC. Half comprehended the seriousness of CRC, the majority understood the benefits of CRC screening, and one-third realized the barriers of CRC screening. Moreover, most understood the importance of preventative medicine and was highly motivated. CONCLUSION: Most Jordanians treated at outpatient clinics comprehend the benefits from CRC screening, understand the seriousness of CRC, and perceive barriers, and more than half of the patients perceive the general health motivation beliefs and outcomes. IMPLICATION FOR PRACTICE: The healthcare system and the decision makers must develop strategies to increase the general population's awareness about CRC and the accompanying screening tests.

King hussein cancer center, leading comprehensive cancer center of excellence

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:59:00 +0000

Pubmed

The King Hussein Cancer Center (KHCC) is the only specialized cancer center in the Middle East that treats both adult and pediatric patients.Founded in 1997, KHCC is a non-governmental, non-profit comprehensive center dedicated entirely to cancer care. It has achieved several international and national recognitions and attained the following accreditations a) Joint Commission International Accreditation (JCIA) - First Institution in Jordan - (Feb, 2006). b) JCI Disease Specific Certification (DSC) - First Cancer Center outside the US - (Nov, 2007). c) JCIA Reaccreditation Certificate (Mar,2009 through Mar,2012) d) College of American Pathologists Accreditation (CAP) - (July, 2009). e) Heath Care Accreditation Council of Jordan (August, 2009). f) Hazardous Analysis and Critical Control Point (HACCP) Systems and Guidelines for its Application- (Apr, 2008). These certificates affirm that KHCC has met the international healthcare quality standards for patient care and organization management KHCC treats over 3500 new cancer patients each year from Jordan and the region. It is equipped with state-of-the-art medical equipment and services including 8 operating rooms and 170 beds. Including 12 adult intensive care unit beds and 6 ICU beds specialized for pediatric care. Currently, our highly qualified oncologists and healthcare professionals (102 oncologists and consultants) and 440 nurses, trained specifically in oncology nursing, work tirelessly to ensure that patients receive the latest in comprehensive cancer care. In addition, KHCC's commitment to continuous education for its entire medical team and healthcare personnel as well as a strong fellowship program makes KHCC a world-class institution.

Oncological services in the Gulf and Arab World. National Oncology Center, Royal Hospital Oman

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:56:00 +0000

Pubmed

Oncological services in the Gulf and Arab World. National Oncology Center, Royal Hospital Oman.

Coping with a diagnosis of breast cancer-literature review and implications for developing countries

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:54:00 +0000

Pubmed

Breast cancer is the most common cancer affecting women worldwide. Women are at an increased risk of developing both physical and psychological morbidity after diagnosis; however, many use different strategies to cope with the disease. The aim of this article is to review the available literature on the impact of breast cancer diagnoses and the strategies used by women to cope with this disease. The implications of these emerging findings are extrapolated within the context of health services provided in developing countries. Electronic databases were used to search the relevant literature. The findings showed that women who were diagnosed with breast cancer are at risk of developing several psychological morbidities such as depression, anxiety, fatigue, negative thoughts, suicidal thoughts, fear of dying, sense of aloneness, sexual and body images problems, as well as an overall decrease in the quality of life. Several strategies are used by women with breast cancer to cope with the disease, including positive cognitive restructuring, wishful thinking, emotional expression, disease acceptance, increased religious practice, family and social support, and yoga and exercise. Breast cancer diagnoses have been associated with several devastating psychological consequences; however, many women have used different coping strategies to adjust their lives accordingly. Healthcare professionals in developing countries, who work with women with breast cancer, should be aware of the different coping mechanisms that women use when diagnosed with cancer. Integrating a coping strategy into the treatment regimen would constitute an important milestone in the palliative care of patients with breast cancer.

A short outpatient hydration schedule for cisplatin administration

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:53:00 +0000

Pubmed

BACKGROUND: Cisplatin remains a principal chemotherapy agent in the treatment of many solid tumours. However because of its nephrotoxicity, inpatient hydration schedules have been utilized to ensure safe administration. In May 1995, due to significant load on in-patient bed availability, the Medical Oncology Department of the Cancer Therapy Centre, Liverpool Hospital, developed a short, intravenous fluid hydration protocol to be used on an out-patient setting. METHODS: Following an initial pilot program of the abbreviated hydration regimen, a retrospective study of all adult in-patients and out-patients who received cisplatin (60-100 mg/m2) from May 1995 to August 1998 was conducted. Biochemistry was performed prior to the start of chemotherapy, and a repeat serum creatinine level was taken immediately prior to each subsequent cycle of chemotherapy, unless clinically indicated at an earlier time. The in-patient hydration protocol was 6000 ml of normal saline with 60 mmol/L KCL, and 30 mmol/L MgSO4 over 24 to 28 hours, and the out-patient hydration was 4000 ml of normal saline over 6 hours. RESULTS: A total of 145 patients were included, 57 in-patient (39%) and 88 out-patients (61%), 95 males, and 50 females. The mean age was 56 years. The maximum mean percentage change in creatinine from baseline for all cycles of chemotherapy for in-patients was 32.5% ranging from -7% to 288% (95% CI=19.9-45.11), and for outpatients 19.9% ranging from -20% to 154% (95% CI=13.47-26.39). Although the mean increase was higher in the in-patient group by 12.6%, it was not statistically significant (p=0.079). CONCLUSION: In patient's eligible for cis-platinum therapy on the basis of good performance status and normal renal function, this agent can be safely administered in the out-patient setting with an abbreviated duration, moderate volume intravenous hydration regimen.

Stem Cell Research in the Greater Middle East: The Importance of Establishing Policy and Ethics Interoperability to Foster International Collaboration

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:51:00 +0000

Pubmed

While fossil fuel reserves have strengthened the economies of numerous countries in the Greater Middle East (GME) for decades, multiple nations within this region are now increasingly investing in internal science and engineering programs as a mechanism to develop more extensive knowledge-based economies. One of these newly pursued disciplines is stem cell research. Nations such as Saudi Arabia and Qatar have founded nascent programs while Iran, Turkey, and Israel are more established in the field. The extent to which these investments have been productive, as measured by publication quantity and impact, remains unknown. Here we assess the state of stem cell research in the GME, report on the policy and ethical considerations facing the region, and determine the impact of international research collaborations in this area. In the majority of the region, there is no legal framework regulating stem cell research. Instead, scientists often rely on religious decrees outlining acceptable practices. These guidelines do not provide the necessary structure to foster international collaborations with nations that have enacted formal laws recognized worldwide. Our results illustrate that international collaborations in the GME produce publications of greater impact despite the fact that political tensions and issues unrelated to science have the potential to dramatically hinder cross-border relationships in the region. Overall, we conclude that the national governments of countries within the GME have the unique opportunity to establish stem cell research policies which confer interoperability between nations to foster crucial international collaborations throughout the region.

Cervical Cancer Screening among Sudanese Women

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:50:00 +0000

Pubmed

BACKGROUND: Worldwide, cervical cancer is one of the three most common female cancers and accounts for over 370,000 new cases each year ( nearly 10% of all cancers). In Sudan, invasive cervical cancers is a leading cause of cancer death among women. METHODS: We conducted a community-based survey of Sudanese women living in Khartoum, from 2003 to 2008. Indicators of cervical cancer screening participation were examined : at least one previous Pap smear and Pap testing in the last 1 year. In Khartoum more than 30% of the ethnic Sudanese women live in the central and northern parts of the city. RESULTS: The overall estimated response rate was 32%, and the cooperation rate was 42%. Our study sample for this analysis included 256 women. Nearly one-half (35%) of the respondents had never had a Pap test, and only 65% been screened recently. Factors independently associated with cervical cancer screening use included marital status, housing type, and age. CONCLUSION: Our findings confirm low levels of cervical cancer screening among Sudanese women. Culturally and linguistically appropriate Pap testing intervention programs for less acculturated Sudanese women should be developed, implemented, and evaluated. KEYWORDS: Cervical cancer, Screening.

PET and PET/CT in the Clinical Management of Colorectal Cancer

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:49:00 +0000

Pubmed

PET/CT is a new imaging technology that has already found a number of clinical applications in oncologic imaging. Widespread introduction into clinical practice started approximately 5 years ago. It can already be stated that the synthesis of structural and metabolic information improves the accuracy of primary staging and the detection of recurrent disease and has the realistic potential to change patient management in up to 30% of cases. PET/CT imaging of Colorectal Malignancies has shown that this new modality has higher specificity and sensitivity than PET alone and in certain settings even when compared to PET and CT viewed side by side. Ongoing and future studies will refine its exact place in the diagnostic work-up of colorectal cancer patients and address how often PET/CT can eliminate the need for other imaging studies that are currently performed for the staging or detection of recurrence in these patients. PET/CT fusion images can directly guide biopsies or surgical interventions. This manuscript highlights on potential clinical applications for PET/CT in colorectal tumors. KEYWORDS: PET/CT, colorectal, cancer, diagnosis, staging and treatment.

Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:45:00 +0000

Pubmed

Curcumin has been shown to induce apoptosis in various malignant cancer cell lines. One mechanism of curcumin-induced apoptosis is through the PI3K/Akt signaling pathway. Akt, also known as protein kinase B (PKB), is a member of the family of phosphatidylinositol 3-OH-kinase regulated Ser/Thr kinases. The active Akt regulates cell survival and proliferation; and inhibits apoptosis. In this study we found that curcumin induces apoptotic cell death in MCF-7 cells, as assessed by MTT assay, DNA ladder formation, PARP cleavage, p53 and Bax induction. At apoptotic inducing concentration, curcumin induces a dramatic Akt phosphorylation, accompanied by an increased phosphorylation of glycogen synthase kinase 3beta (GSK3beta), which has been considered to be a pro-growth signaling molecule. Combining curcumin with PI3K inhibitor, LY290042, synergizes the apoptotic effect of curcumin. The inhibitor LY290042 was capable of attenuating curcumin-induced Akt phosphorylation and activation of GSK3beta. All together, our data suggest that blocking the PI3K/Akt survival pathway sensitizes the curcumin-induced apoptosis in MCF-7 cells. Copyright © 2010. Published by Elsevier Inc.

Focus on breast and prostate cancer prevention, early detection and new trends in management highlights of the 1st conference on cancer control

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:44:00 +0000

Pubmed

Kuwait held its first National Conference on Cancer Control on the 9th and 10th of November 2009. It took place in Salwa Al Sabah Ballroom, Marina Hotel, Kuwait. The conference had the honour of being inaugurated by His Excellency Dr. Hilal Al Sayer, Minister of Health, Kuwait. The conference was efficiently organized by Dr. Medhat Oteifa, Head of Surgical Department, KCCC, Dr. Khaled Al Saleh, Head of Radiation Oncology Department, KCCC, and Dr. Abdulla Behbehani, Kuwait University. The conference was a great chance for multiple specialties interested in the field of early detection, programme.

Genomic instability and rapid clinical course in adult T-cell lymphoma/leukemia patient

noreply@blogger.com (Gulfoncology) — Sun, 14 Mar 2010 00:43:00 +0000

Pubmed

Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the minority of patients who are virus carriers. Karyotyping findings and their correlation with clinical features are still limited in T-cell malignancies, complicated by clinical heterogeneity and a plethora of secondary abnormalities. This study describes detailed chromosomal and fluorescence in situ hybridization results observed in a patient with adult T-cell leukemia/lymphoma and correlates them with clinical characteristics. Copyright © 2010 Elsevier Ltd. All rights reserved.

Prevalence of HCV among Yemeni patients with non-Hodgkin's lymphoma at AI-Thawra teaching hospital.

noreply@blogger.com (Gulfoncology) — Sat, 13 Mar 2010 14:25:00 +0000

Pubmed

BACKGROUND: Epidemiological studies in different parts of the world have revealed controversial results on the association between HCV infection and Non-Hodgkin's lymphomas. This discrepancy suggests that HCV lymphotropism and its effect on host lymphocytes may be influenced by regional and racial factors as well as by viral genomic variations. OBJECTIVES: To determine the prevalence of HCV infection in Yemeni patients with NHLs diagnosed and treated in our hospital and to evaluate the association between the two diseases. METHODS: All consecutive patients with NHL treated in our Haematology/Oncology Unit between January 2005 and January 2007 were screened for anti- HCV antibodies by enzyme immunoassay. The prevalence of HCV infection in patients with NHLs was compared to that in a non-lymphomatous control group consisted of all patients checked for HCV infection with several acute medical conditions in the same hospital who were coming from different parts of the country. RESULTS: A total of 192 patients with NHLs were tested for anti-HCV antibodies. One hundred seventeen patients (60.94%) were males and 75 patients (39.06%) were females. The mean age of the patients was 41.30+/-19.15 SD and range between 5-80 years. Twenty-nine (15.1%) of the 192 patients were found positive for HCV infection. Twenty-one (17.6%) of 29 positive patients were male and only 8 (10.7%) patients were female. The mostly involved age group was 41-60 representing 24.6%. A total of 20329 patients from different departments were investigated for anti-HCV antibodies and used as a control. Of the 12274 control (60.4%) were males and 8055 (39.6%) were females. A total of 814 (4%) controls were found positive for HCV antibodies. Of the positive controls, 529 (4.3%) were males and 285 (3.5%) were females. The association between HCV infection and NHLs was assessed using logistic regression models. There was a significant association of HCV with NHLs, the unadjusted OR [4.27, 95% CI 2.86-6.37] which differ slightly by gender in males the OR [4.86, 95% CI 3.01 - 7.85] and in female the OR [3.26, 95%CI 1.55- 6.84]. For separate NHL subtypes, the numbers of HCV infected cases were limited. Nonetheless, positive associations were noted for indolent type [OR=4.49, 95% CI 1.87-10.78] and for aggressive type as well [OR=4.2195% CI 2.69-6.59]. The prevalence of HCV antibodies in cases and controls was more frequent in males and in the age group above 40 years. CONCLUSION: In conclusion the results of the present study indicate a higher prevalence of HCV infection among Yemeni patients with NHL than among persons in the control group. Therefore our study demonstrates an association between HCV infection and NHLs. HCV infection may play a role in causing NHLs.

Pattern of head and neck cancer in yemen.

noreply@blogger.com (Gulfoncology) — Sat, 13 Mar 2010 14:22:00 +0000

Pubmed

Head and neck cancer constitutes one of the commonest malignancies in Yemen. There may be a role for the use of Shamma and Zarda and Khat for the increase of HNC in Yemen. This study was conducted retrospectively with an overall aim to describe the pattern of head and neck cancers among Yemeni patients attending the Oncology Department of Al-Gamhouria Teaching Hospital, Aden, for the period from Jan. 2001 to Dec. 2004. The study included 183 patients with head and neck cancers (Lymphoma and thyroid were excluded), 134 were males (73.2%) and 49 were females (26.8%) , with male to female ratio of 2.7:1. The mean age was 51.3 +/- 14.9 years (range: 3 - 82 years). Statistically, there is significant difference between the mean age of male (49.5 +/- 15.1 years) and female (45.4 +/- 16.3 years) patients with head and neck cancers [t= 2.1, p: 0.03]. The common types of head and neck cancers in this study are cancers of the oral cavity (31.7%), followed by pharyngeal (22.9%) and laryngeal (19.1%). In relation to sex, there is a significant statistical relationship between certain head and neck cancers and sex (p: 0.0000). In males, the common cancers are oral cavity cancers (22.7%), laryngeal (22.1%) and pharyngeal cancers (20.8%). The common histopathological type of head and neck cancers in this study is the well differentiated squamous cell carcinoma (70.5%). This study concluded that head and neck cancers are among the common health problems affecting Yemeni patients and recommended further wide national studies to determine the real incidence and the risk factors associated with such cancer. KEYWORDS: Head and neck, cancer, Squamous cell carcinoma.

Comparison of bone marrow aspiration and bone marrow biopsy in neoplastic diseases

noreply@blogger.com (Gulfoncology) — Sat, 13 Mar 2010 14:21:00 +0000

Pubmed

Naturally trephine biopsies have definitive advantages over aspirates in case of dry tap bone marrow aspirates as a result of fibrosis or densely packed bone marrow by tumour cells and may be informative independent of cytology especially in bone marrow involvement by lymphomas and carcinomas. In this prospective descriptive study we aimed to compare between the bone marrow trephine biopsy (BMTB) and bone marrow aspirates (BMAs) regarding the detection rate of solid tumours, lymphoma and myeloma involvement of the bone marrow. The study was carried out in the department of pathology and Haematology-Oncology of Al-Gamhouria Teaching Hospital/Aden during the period between Jan 2005 to Dec 2005. A total of 32 patients with suspected or confirmed malignancy undergone both BMTB and BMA from the posterior superior iliac crest and both results were compared. We divided them into three groups: those with solid tumours (21) patients, lymphoma (7) patients and with MM (4) patients. Our results showed that BMA had a 47.6% sensitivity, 100.0% specificity, with positive predictive value (100%), and negative predictive value (50.0%). In solid tumours alone it had a sensitivity of (40.0%), 100% specificity, with positive predictive value (100%), and negative predictive value (64.7%). This gives the BMA a lower sensitivity in detecting solid tumour metastasis and lymphoma involvement in comparison to BMTB. In conclusion, any patient with suspected or confirmed cancer should un

Stem Cell Research in the Greater Middle East: The Importance of Establishing Policy and Ethics Interoperability to Foster International Collaboration

noreply@blogger.com (Gulfoncology) — Sat, 13 Mar 2010 14:19:00 +0000

فحص 400 سيدة يكشف إصابة 6 بسرطان الثدي في الشرقية

noreply@blogger.com (Gulfoncology) — Sat, 13 Mar 2010 14:16:00 +0000

أشار رئيس جمعية السرطان السعودية بالمنطقة الشرقية عبد العزيز التركي إلى اكتشاف إصابة 6 سيدات بسرطان الثدي ضمن معاينة 400 سيدة في سيارة الماموجرام" التي دشنتها حملة "الشرقية وردية" في شهر أكتوبر الماضي. واصفا هذه النسبة بالمرتفعة التي تشكل خطرا على النساء بالمملكة, وأرجع تحويل 60 حالة منها لإجراء فحوصات رسمية بالمستشفيات المتخصصة إلى الاشتباه في إصابتهن بالسرطان وهو الأمر الذي ينعكس ايجابيا على شفاء المصابات بعد تلقي العلاج في مراحل المرض المبكرة. موضحا أن برامج الحملات التوعوية السابقة استطاعت الكشف على ما يقارب 8 آلاف امرأة منهن 50 سيدة يتلقين العلاج حاليا بالشرقية إثر إصابتهن بسرطان الثدي. جاء ذلك خلال انعقاد الجمعية العمومية الثالثة في دورتها الثانية بمستشفى الملك فهد الجامعي بالخبر بحضور أعضاء مجلس إدارة جمعية السرطان ورؤساء اللجان وممثل وزارة الشؤون الاجتماعية محمد الصفيان.
وأكد التركي عزم الجمعية تطبيق مشروع "سيارة الماموجرام" في القطيف والاحساء قريبا بعد أن افتتحت مؤخرا مكتبها بالقطيف، حيث تم تعيين سلمان الجشي رئيسا تنفيذيا لهذا الفرع الجديد في الوقت الذي وافقت فيه الجمعية العمومية على فتح فروع أخرى بمحافظات المنطقة الشرقية لرعاية مرضى السرطان وتوعية أفراد المجتمع بمخاطر هذا المرض. مبينا أن رعاية صاحب السمو الملكي الأمير محمد بن فهد أمير المنطقة الشرقية المؤتمر الثالث وحملة "الشرقية وردية" أكسب الجمعية دعما كبيرا وتشريفا لكافة الأنشطة والفعاليات المختلفة التي تنظمها وتشرف عليها في سبيل تحقيق مسئوليتها الاجتماعية, وأوضح التركي خلال تقديمه تقريرا عن أعمال جمعية السرطان السعودية بالمنطقة الشرقية العام الماضي إلى النتائج الإيجابية التي حققتها الجمعية عبر مؤتمراتها وندواتها المتخصصة، إضافة إلى توقيعها لاتفاقية التعاون مع الجامعة الأمريكية في بيروت وابتعاثها طبيبا سعوديا للاستفادة من العلوم الطبية التي تقدمها الجامعة في مجال السرطان. مبينا أن الجمعية وضعت نصب عينيها تثقيف الأفراد بأمراض السرطان المختلفة قبل تأسيسها منذ ستة أعوام تقريبا.

Saudi Cancer Foundation

noreply@blogger.com (Gulfoncology) — Sat, 20 Feb 2010 17:52:00 +0000

Saudi Cancer Foundation, in collaboration with the Health Education Department at Armed Forces Hospital in Dhahran, is pleased to invite you to register for:

Brain Tumors Symposium
Venue: Saudi Aramco Exhibition, Dhahran
February 25, 2010 – 08:00am to 02:00pm

3 CME from SCFHS
3.5 CME from American Academy for CME

يسر جمعية السرطان السعودية بالتعاون مع إدارة التثقيف والتدريب الطبي بمستشفى القوات المسلحة بالظهران، دعوتكم لحضور الندوة الطبية عن سرطان المخ، وذلك يوم الخميس 25 فبراير 2010 في معرض أرامكو السعودية بالظهران، من الساعة 8 صباحا وحتى الثانية ظهرا.

3 ساعات تعليمية معتمدة من هيئة التخصصات الصحية
3.5 ساعات تعليمية معتمدة من الأكاديمية الأمريكية للتعليم الطبي المستمر

Saudi Oncology Society

noreply@blogger.com (Gulfoncology) — Sat, 20 Feb 2010 04:44:00 +0000

Dear Saudi Oncology Society Members;

It is our pleasure to invite you to attend the First Scientific Annual Conference of the Saudi Oncology Society (International Cancer Care Conference) which will be held on 9-11 March, 2010 at Le Gulf Meridien Hotel, Alkhobar, Saudi Arabia. Speakers will come from well recognized hospital and medical institutes in USA, UK, Jordan and kingdom of Saudi Arabia and will present the latest updates in oncology field.

A special workshop entitled “Palliative Care perspective of Pain Management” will be on 9th of march, 2010, where three groups will practice the latest technique in Pain management.

A special course entitled “ONS Certification” was added to the conference agenda and attendees will get the “Oncology Nursing Society Chemotherapy and Biotherapy Course” certificate. ONS is accredited as a provider of continuing nursing education by theAmerican Nurses Credentialing Center’s Commission on Accreditation.

For more information
Please contact: Saed Al-Harthi, 0569336119, info@oncology.org.sa ,http://www.oncology.org.sa/.

“Pediatric and Developmental Pathology” on a case of mediastinal lipoblastomatosis with unusual complex Karyotype.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:32:00 +0000

By Dr Samir Amr

Pediatric and Developmental Pathology 12, 469–474, 2009

رئيسة حملة الكشف المبكر عن سرطان الثدي لـ اليوم

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:26:00 +0000

رئيسة حملة الكشف المبكر عن سرطان الثدي لـ اليوم

جهود الأمير محمد بن فهد وحرمه لها أكبر الأثر في نجاح الحملة

الشرقية الأعلى في نسب الإصابة بسرطان الثدي لدى النساء

هنادي الغدير - الدمام

أكدت الدكتورة فاطمة الملحم أن 22بالمائة من مجموع السعوديات المصابات بالسرطان في المملكة هن مصابات بسرطان الثدي حسب الإحصائيات الأخيرة التي صدرت عن مركز الاحصاء الوطني ووزارة الصحة السعودية وطالبت بسرعة الوصول إلى المصابين بالمرض في مراحله الأولى، لأنه عندما تكتشف المرأة إصابتها مبكراً، فإن نسبة الشفاء لديها تصل إلى 95 بالمائة في كثير من الحالات خصوصاً أن الكثير من الحالات في المملكة يُشخص في مراحل متأخرة ، مشيرة الى ان آخر تقرير صدر عن سجل الأورام السعودي عام 2005 م ، تم خلاله تشخيص 1000 حالة سرطان ثدي، شكلت المنطقة الشرقية منها 30 بالمائة وتعد أعلى نسبة على مستوى المملكة، مقدمة شكرها لصاحب السمو الملكي الأمير محمد بن فهد أمير المنطقة الشرقية وسمو حرمه صاحبة السمو الملكي الأميرة جواهر بنت نايف على دعمهما أول مشروع للفحص المتنقل لسرطان الثدي ...
«اليوم» التقطت بها وأجرت معها هذا الحوار السريع :
كيف بدأت فكرة إجراء الكشف المبكر عن سرطان الثدي من خلال سيارة متنقلة ؟
بدأت فكرة إجراء الكشف المبكر عن سرطان الثدي من خلال سيارة متنقلة قبل سنتين، عندما قمت بطرح المشروع على الجمعية السعودية للسرطان، التي استضافت عددا من رجال الأعمال لشرح الفكرة والمساهمة بالتبرع من أجل تحويلها إلى واقع ملموس يخدم شرائح المجتمع النسائي في المنطقة الشرقية ، وبالفعل لاقت الفكرة نجاحاً كبيرا، وكان أول المتبرعين صاحب السمو الملكي الأمير محمد بن فهد أمير المنطقة الشرقية.
المستفيدات
من المستفيدات من سيارات الكشف المبكر عن سرطان الثدي ؟
المستفيدات هن السيدات السليمات اللاتي تجاوزت أعمارهن الأربعين عاماً . ففي الأسبوع الماضي تقدمت للكشف 33 سيدة، كشف بينهن عن وجود 3 حالات مصابة بالسرطان.
سيارة الكشف
ما خطة عمل سيارة الكشف المبكر عن سرطان الثدي ؟
تواجدت سيارة الكشف المبكر عن سرطان الثدي أول شهرين في مستشفى الملك فهد التعليمي بالخبر ، وهي حاليا متواجدة في مستشفى الخبر الحكومي، حيث سيتم من خلال موقعها مسح مدينة الخبر للتأكد من استكمال الكشف عن أغلب سيدات المدينة السليمات ممن تجاوزن الاربعين من عمرهن عن طريق سجلات المرضى المسجلة لدى وزارة الصحة، يلي ذلك انتقالها لمدينة الدمام ثم باقي مناطق المنطقة الشرقية.
دعم أمير الشرقية
كيف كان دعم الأمير محمد بن فهد أمير المنطقة الشرقية للحملة ؟
كان لدعم الأمير محمد بن فهد السخي «مادياً ومعنوياً» أبلغ الأثر في نجاح مشروع الكشف المبكر عن سرطان الثدي. فلم يقصر منذ بداية الفكرة وحتى بعدها. فقد حظينا بتواجد ممثلين عن سموه في جميع الحملات. ففي يوم الافتتاح لحملة «الشرقية وردية» أناب وكيل إمارة المنطقة الشرقية زارب القحطاني.
الأميرة جواهر
كيف ترون مساهمة صاحبة السمو الملكي الأميرة جواهر بنت نايف في دعم الحملة ؟
لقد ساهمت الأميرة جواهر في تدشين حملة الكشف المبكر عن سرطان الثدي في شهر مايو 2009 م وجادت بتبرع سخي أثناء الحملة وبعدها، وهي متابعة لأنشطتنا وما نقوم به في هذا المجال من فعاليات ونحن من هنا نتقدم لها بكل الشكر والتقدير على ما تقوم به من جهود لخدمة سيدات المنطقة الشرقية.
1000 حالة
كم عدد حالات سرطان الثدي في المنطقة الشرقية ؟
ما لا يعرفه الكثيرون أنه في آخر تقرير صدر عن سجل الأورام السعودي عام 2005 م، تم تشخيص 1000 حالة سرطان ثدي، شكلت المنطقة الشرقية منها 30 بالمائة وهي تعد أعلى نسبة على مستوى المملكة.
رجال وسيدات الأعمال
ماذا تتمنى الدكتورة فاطمة الملحم من رجال وسيدات الأعمال ؟
أتمنى منهم جميعاً المساهمة الفعالة في خدمة أهالي المنطقة الشرقية من خلال هذه الحملة. فسيارة واحدة لا تكفي لتغطية جميع مدن المنطقة الشرقية. بلدنا والحمد لله خير وأهله خيرون يسعون لكل ما فيه خدمة مجتمعهم، وكون سيدات المنطقة الشرقية يحملن أعلى نسبة للإصابة بمرض السرطان فأنا أطالب رجال الأعمال وأهل الخير بتبني فكرة دعم كراسي البحث العلمي لدى الجامعات لعمل دراسات حول مسببات سرطان الثدي وارتفاع نسبه بين سيدات المنطقة الشرقية.
تواصل مع المستشفيات
كيف يتم تواصلكم مع المستشفيات في حال ثبوت حالة مصابة بسرطان الثدي ؟
توجد اتفاقيات بيننا وبين مستشفى الملك فهد الجامعي بالخبر ومستشفى الملك فهد التخصصي بالدمام فيما يخص تحويل أي حالة مصابة إليهم لعمل الإجراءات واتخاذ اللازم.
أهمية الفحص
كيف تتم توعية المجتمع بأهمية الفحص الدوري للكشف عن سرطان الثدي ؟
يتم ذلك من خلال الأنشطة المستمرة والمحاضرات الدورية والزيارات لمراكز الحي والجامعات والكليات والمدارس، وجدولنا حافل بالكثير منها. فلدينا دورة تحمل عنوان «دقيقتان أنقذتا حياتي « وفيها نقوم بتدريب أطباء وطبيبات الرعاية الأولية والولادة والنساء على شرح أهمية الفحص الذاتي مرة كل شهر بعد الدورة الشهرية للسيدات، إضافة إلى محاضرات عن سرطان الثدي و جراحة الثدي وغير ذلك.

بطاقة تعريف
الاسم : فاطمة بنت عبد الله خليفة الملحم
أستاذة ورئيسة قسم الأشعة في مستشفى الملك فهد الجامعي بالخبر
أول طبيبة أشعة بالمنطقة الشرقية
رئيسة حملة «الكشف المبكر عن سرطان الثدي بالمنطقة الشرقية»
عضو في الجمعية السعودية للسرطان

Saline infusion sonohysterography - an effective tool for evaluation of the endometrial cavity in women with abnormal uterine bleeding

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:24:00 +0000

Pubmed

Mathew M, Gowri V, Rizvi SG.
Department of Obstetrics and Gynecology, Sultan Qaboos University, Muscat, Oman.
We evaluated the diagnostic accuracy of saline infusion sonohysterography (SISH) over transvaginal sonography (TVS) for the detection of intrauterine abnormalities using hysteroscopy as the gold standard in a retrospective study of 70 women mostly presenting with abnormal uterine bleeding. TVS was normal in 32 women, while in the others polyps or fibroids projecting into the cavity (n = 19) or a thick endometrium (n = 19) were suspected. On performing SISH the uterine cavity was found to be normal in 29 women, while 35 had suspected polyps/fibroids and 6 had other abnormalities. Hysteroscopy proved to be normal in 28 women, 35 had polyps/fibroids and 7 had other abnormalities. The sensitivity, specificity, positive and negative predictive values for TVS were 72.4%, 100%, 100% and 74%, respectively, while for SISH the corresponding figures were 91.4%, 92.6%, 89.3% and 94.1%. SISH is a simple, minimally invasive and cost-effective investigative tool enhancing the diagnostic accuracy of TVS and can be an effective screening test prior to hysteroscopy.

A short outpatient hydration schedule for cisplatin administration.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:22:00 +0000

Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:20:00 +0000

Pubmed

Hussain AR, Khan AS, Ahmed SO, Ahmed M, Platanias LC, Al-Kuraya KS, Uddin S.
Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Abstract Objective: The mechanisms that regulate mitogenic and antiapoptotic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we assessed the effect of apigenin (4',5,7-trihydroxyflavone), a flavonoid on a panel of PEL cell lines. Materials and methods: We studied the effect of apigenin on four PEL cell lines. Apoptosis was measured by annexin V/PI dual staining and DNA laddering. Protein expression was measured by immunoblotting. Results: Apigenin induced apoptosis in PEL cell lines in a dose dependent manner. Such effects of apigenin appeared to result from suppression of constitutively active kinase AKT resulting in down-regulation of SKP2, hypo-phosphorylation of Rb and accumulation of p27Kip1. Apigenin treatment of PEL cells caused dephosphorylation of p-Bad protein leading to down regulation of the anti-apoptotic protein, Bcl-2 and an increase in Bax/Bcl2 ratio. Apigenin treatment also triggered Bax conformational change and subsequently translocation from cytosole to mitochondria causing loss of mitochondrial membrane potential with subsequent release of cytochrome c. Released cytochrome c onto the cytosole activated caspase-9 and caspase-3, followed by polyadenosin-5'-diphosphate-ribose polymerase (PARP) cleavage. Finally, treatment of PEL cells with apigenin down-regulated the expression of inhibitor of apoptosis protein (IAPs). Conclusions: Altogether, these data suggest a novel function for apigenin, acting as a suppressor of AKT/PKB pathway in PEL cells, and raise the possibility that this agent may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of the AKT/PKB pathway.