Araboncology

Saudi Cancer Foundation

noreply@blogger.com (Gulfoncology) — Sat, 20 Feb 2010 17:52:00 +0000

Saudi Cancer Foundation, in collaboration with the Health Education Department at Armed Forces Hospital in Dhahran, is pleased to invite you to register for:

Brain Tumors Symposium
Venue: Saudi Aramco Exhibition, Dhahran
February 25, 2010 – 08:00am to 02:00pm

3 CME from SCFHS
3.5 CME from American Academy for CME

يسر جمعية السرطان السعودية بالتعاون مع إدارة التثقيف والتدريب الطبي بمستشفى القوات المسلحة بالظهران، دعوتكم لحضور الندوة الطبية عن سرطان المخ، وذلك يوم الخميس 25 فبراير 2010 في معرض أرامكو السعودية بالظهران، من الساعة 8 صباحا وحتى الثانية ظهرا.

3 ساعات تعليمية معتمدة من هيئة التخصصات الصحية
3.5 ساعات تعليمية معتمدة من الأكاديمية الأمريكية للتعليم الطبي المستمر

Saudi Oncology Society

noreply@blogger.com (Gulfoncology) — Sat, 20 Feb 2010 04:44:00 +0000

Dear Saudi Oncology Society Members;

It is our pleasure to invite you to attend the First Scientific Annual Conference of the Saudi Oncology Society (International Cancer Care Conference) which will be held on 9-11 March, 2010 at Le Gulf Meridien Hotel, Alkhobar, Saudi Arabia. Speakers will come from well recognized hospital and medical institutes in USA, UK, Jordan and kingdom of Saudi Arabia and will present the latest updates in oncology field.

A special workshop entitled “Palliative Care perspective of Pain Management” will be on 9th of march, 2010, where three groups will practice the latest technique in Pain management.

A special course entitled “ONS Certification” was added to the conference agenda and attendees will get the “Oncology Nursing Society Chemotherapy and Biotherapy Course” certificate. ONS is accredited as a provider of continuing nursing education by theAmerican Nurses Credentialing Center’s Commission on Accreditation.

For more information
Please contact: Saed Al-Harthi, 0569336119, info@oncology.org.sa ,http://www.oncology.org.sa/.

“Pediatric and Developmental Pathology” on a case of mediastinal lipoblastomatosis with unusual complex Karyotype.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:32:00 +0000

By Dr Samir Amr

Pediatric and Developmental Pathology 12, 469–474, 2009

رئيسة حملة الكشف المبكر عن سرطان الثدي لـ اليوم

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:26:00 +0000

رئيسة حملة الكشف المبكر عن سرطان الثدي لـ اليوم

جهود الأمير محمد بن فهد وحرمه لها أكبر الأثر في نجاح الحملة

الشرقية الأعلى في نسب الإصابة بسرطان الثدي لدى النساء

هنادي الغدير - الدمام

أكدت الدكتورة فاطمة الملحم أن 22بالمائة من مجموع السعوديات المصابات بالسرطان في المملكة هن مصابات بسرطان الثدي حسب الإحصائيات الأخيرة التي صدرت عن مركز الاحصاء الوطني ووزارة الصحة السعودية وطالبت بسرعة الوصول إلى المصابين بالمرض في مراحله الأولى، لأنه عندما تكتشف المرأة إصابتها مبكراً، فإن نسبة الشفاء لديها تصل إلى 95 بالمائة في كثير من الحالات خصوصاً أن الكثير من الحالات في المملكة يُشخص في مراحل متأخرة ، مشيرة الى ان آخر تقرير صدر عن سجل الأورام السعودي عام 2005 م ، تم خلاله تشخيص 1000 حالة سرطان ثدي، شكلت المنطقة الشرقية منها 30 بالمائة وتعد أعلى نسبة على مستوى المملكة، مقدمة شكرها لصاحب السمو الملكي الأمير محمد بن فهد أمير المنطقة الشرقية وسمو حرمه صاحبة السمو الملكي الأميرة جواهر بنت نايف على دعمهما أول مشروع للفحص المتنقل لسرطان الثدي ...
«اليوم» التقطت بها وأجرت معها هذا الحوار السريع :
كيف بدأت فكرة إجراء الكشف المبكر عن سرطان الثدي من خلال سيارة متنقلة ؟
بدأت فكرة إجراء الكشف المبكر عن سرطان الثدي من خلال سيارة متنقلة قبل سنتين، عندما قمت بطرح المشروع على الجمعية السعودية للسرطان، التي استضافت عددا من رجال الأعمال لشرح الفكرة والمساهمة بالتبرع من أجل تحويلها إلى واقع ملموس يخدم شرائح المجتمع النسائي في المنطقة الشرقية ، وبالفعل لاقت الفكرة نجاحاً كبيرا، وكان أول المتبرعين صاحب السمو الملكي الأمير محمد بن فهد أمير المنطقة الشرقية.
المستفيدات
من المستفيدات من سيارات الكشف المبكر عن سرطان الثدي ؟
المستفيدات هن السيدات السليمات اللاتي تجاوزت أعمارهن الأربعين عاماً . ففي الأسبوع الماضي تقدمت للكشف 33 سيدة، كشف بينهن عن وجود 3 حالات مصابة بالسرطان.
سيارة الكشف
ما خطة عمل سيارة الكشف المبكر عن سرطان الثدي ؟
تواجدت سيارة الكشف المبكر عن سرطان الثدي أول شهرين في مستشفى الملك فهد التعليمي بالخبر ، وهي حاليا متواجدة في مستشفى الخبر الحكومي، حيث سيتم من خلال موقعها مسح مدينة الخبر للتأكد من استكمال الكشف عن أغلب سيدات المدينة السليمات ممن تجاوزن الاربعين من عمرهن عن طريق سجلات المرضى المسجلة لدى وزارة الصحة، يلي ذلك انتقالها لمدينة الدمام ثم باقي مناطق المنطقة الشرقية.
دعم أمير الشرقية
كيف كان دعم الأمير محمد بن فهد أمير المنطقة الشرقية للحملة ؟
كان لدعم الأمير محمد بن فهد السخي «مادياً ومعنوياً» أبلغ الأثر في نجاح مشروع الكشف المبكر عن سرطان الثدي. فلم يقصر منذ بداية الفكرة وحتى بعدها. فقد حظينا بتواجد ممثلين عن سموه في جميع الحملات. ففي يوم الافتتاح لحملة «الشرقية وردية» أناب وكيل إمارة المنطقة الشرقية زارب القحطاني.
الأميرة جواهر
كيف ترون مساهمة صاحبة السمو الملكي الأميرة جواهر بنت نايف في دعم الحملة ؟
لقد ساهمت الأميرة جواهر في تدشين حملة الكشف المبكر عن سرطان الثدي في شهر مايو 2009 م وجادت بتبرع سخي أثناء الحملة وبعدها، وهي متابعة لأنشطتنا وما نقوم به في هذا المجال من فعاليات ونحن من هنا نتقدم لها بكل الشكر والتقدير على ما تقوم به من جهود لخدمة سيدات المنطقة الشرقية.
1000 حالة
كم عدد حالات سرطان الثدي في المنطقة الشرقية ؟
ما لا يعرفه الكثيرون أنه في آخر تقرير صدر عن سجل الأورام السعودي عام 2005 م، تم تشخيص 1000 حالة سرطان ثدي، شكلت المنطقة الشرقية منها 30 بالمائة وهي تعد أعلى نسبة على مستوى المملكة.
رجال وسيدات الأعمال
ماذا تتمنى الدكتورة فاطمة الملحم من رجال وسيدات الأعمال ؟
أتمنى منهم جميعاً المساهمة الفعالة في خدمة أهالي المنطقة الشرقية من خلال هذه الحملة. فسيارة واحدة لا تكفي لتغطية جميع مدن المنطقة الشرقية. بلدنا والحمد لله خير وأهله خيرون يسعون لكل ما فيه خدمة مجتمعهم، وكون سيدات المنطقة الشرقية يحملن أعلى نسبة للإصابة بمرض السرطان فأنا أطالب رجال الأعمال وأهل الخير بتبني فكرة دعم كراسي البحث العلمي لدى الجامعات لعمل دراسات حول مسببات سرطان الثدي وارتفاع نسبه بين سيدات المنطقة الشرقية.
تواصل مع المستشفيات
كيف يتم تواصلكم مع المستشفيات في حال ثبوت حالة مصابة بسرطان الثدي ؟
توجد اتفاقيات بيننا وبين مستشفى الملك فهد الجامعي بالخبر ومستشفى الملك فهد التخصصي بالدمام فيما يخص تحويل أي حالة مصابة إليهم لعمل الإجراءات واتخاذ اللازم.
أهمية الفحص
كيف تتم توعية المجتمع بأهمية الفحص الدوري للكشف عن سرطان الثدي ؟
يتم ذلك من خلال الأنشطة المستمرة والمحاضرات الدورية والزيارات لمراكز الحي والجامعات والكليات والمدارس، وجدولنا حافل بالكثير منها. فلدينا دورة تحمل عنوان «دقيقتان أنقذتا حياتي « وفيها نقوم بتدريب أطباء وطبيبات الرعاية الأولية والولادة والنساء على شرح أهمية الفحص الذاتي مرة كل شهر بعد الدورة الشهرية للسيدات، إضافة إلى محاضرات عن سرطان الثدي و جراحة الثدي وغير ذلك.

بطاقة تعريف
الاسم : فاطمة بنت عبد الله خليفة الملحم
أستاذة ورئيسة قسم الأشعة في مستشفى الملك فهد الجامعي بالخبر
أول طبيبة أشعة بالمنطقة الشرقية
رئيسة حملة «الكشف المبكر عن سرطان الثدي بالمنطقة الشرقية»
عضو في الجمعية السعودية للسرطان

Saline infusion sonohysterography - an effective tool for evaluation of the endometrial cavity in women with abnormal uterine bleeding

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:24:00 +0000

Pubmed

Mathew M, Gowri V, Rizvi SG.
Department of Obstetrics and Gynecology, Sultan Qaboos University, Muscat, Oman.
We evaluated the diagnostic accuracy of saline infusion sonohysterography (SISH) over transvaginal sonography (TVS) for the detection of intrauterine abnormalities using hysteroscopy as the gold standard in a retrospective study of 70 women mostly presenting with abnormal uterine bleeding. TVS was normal in 32 women, while in the others polyps or fibroids projecting into the cavity (n = 19) or a thick endometrium (n = 19) were suspected. On performing SISH the uterine cavity was found to be normal in 29 women, while 35 had suspected polyps/fibroids and 6 had other abnormalities. Hysteroscopy proved to be normal in 28 women, 35 had polyps/fibroids and 7 had other abnormalities. The sensitivity, specificity, positive and negative predictive values for TVS were 72.4%, 100%, 100% and 74%, respectively, while for SISH the corresponding figures were 91.4%, 92.6%, 89.3% and 94.1%. SISH is a simple, minimally invasive and cost-effective investigative tool enhancing the diagnostic accuracy of TVS and can be an effective screening test prior to hysteroscopy.

A short outpatient hydration schedule for cisplatin administration.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:22:00 +0000

Pubmed

BACKGROUND: Cisplatin remains a principal chemotherapy agent in the treatment of many solid tumours. However because of its nephrotoxicity, inpatient hydration schedules have been utilized to ensure safe administration. In May 1995, due to significant load on in-patient bed availability, the Medical Oncology Department of the Cancer Therapy Centre, Liverpool Hospital, developed a short, intravenous fluid hydration protocol to be used on an out-patient setting. METHODS: Following an initial pilot program of the abbreviated hydration regimen, a retrospective study of all adult in-patients and out-patients who received cisplatin (60-100 mg/m2) from May 1995 to August 1998 was conducted. Biochemistry was performed prior to the start of chemotherapy, and a repeat serum creatinine level was taken immediately prior to each subsequent cycle of chemotherapy, unless clinically indicated at an earlier time. The in-patient hydration protocol was 6000 ml of normal saline with 60 mmol/L KCL, and 30 mmol/L MgSO4 over 24 to 28 hours, and the out-patient hydration was 4000 ml of normal saline over 6 hours. RESULTS: A total of 145 patients were included, 57 in-patient (39%) and 88 out-patients (61%), 95 males, and 50 females. The mean age was 56 years. The maximum mean percentage change in creatinine from baseline for all cycles of chemotherapy for in-patients was 32.5% ranging from -7% to 288% (95% CI=19.9-45.11), and for outpatients 19.9% ranging from -20% to 154% (95% CI=13.47-26.39). Although the mean increase was higher in the in-patient group by 12.6%, it was not statistically significant (p=0.079). CONCLUSION: In patient's eligible for cis-platinum therapy on the basis of good performance status and normal renal function, this agent can be safely administered in the out-patient setting with an abbreviated duration, moderate volume intravenous hydration regimen.

Apigenin induces apoptosis via downregulation of S-phase kinase-associated protein 2-mediated induction of p27Kip1 in primary effusion lymphoma cells.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:20:00 +0000

Pubmed

Hussain AR, Khan AS, Ahmed SO, Ahmed M, Platanias LC, Al-Kuraya KS, Uddin S.
Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Abstract Objective: The mechanisms that regulate mitogenic and antiapoptotic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we assessed the effect of apigenin (4',5,7-trihydroxyflavone), a flavonoid on a panel of PEL cell lines. Materials and methods: We studied the effect of apigenin on four PEL cell lines. Apoptosis was measured by annexin V/PI dual staining and DNA laddering. Protein expression was measured by immunoblotting. Results: Apigenin induced apoptosis in PEL cell lines in a dose dependent manner. Such effects of apigenin appeared to result from suppression of constitutively active kinase AKT resulting in down-regulation of SKP2, hypo-phosphorylation of Rb and accumulation of p27Kip1. Apigenin treatment of PEL cells caused dephosphorylation of p-Bad protein leading to down regulation of the anti-apoptotic protein, Bcl-2 and an increase in Bax/Bcl2 ratio. Apigenin treatment also triggered Bax conformational change and subsequently translocation from cytosole to mitochondria causing loss of mitochondrial membrane potential with subsequent release of cytochrome c. Released cytochrome c onto the cytosole activated caspase-9 and caspase-3, followed by polyadenosin-5'-diphosphate-ribose polymerase (PARP) cleavage. Finally, treatment of PEL cells with apigenin down-regulated the expression of inhibitor of apoptosis protein (IAPs). Conclusions: Altogether, these data suggest a novel function for apigenin, acting as a suppressor of AKT/PKB pathway in PEL cells, and raise the possibility that this agent may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of the AKT/PKB pathway.

Biallelic p.R2223H Mutation in the Thyroglobulin Gene Causes Thyroglobulin Retention and Severe Hypothyroidism with Subsequent Development of Thyroid

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:18:00 +0000

Pubmed

Raef H, Al-Rijjal R, Al-Shehri S, Zou M, Al-Mana H, Baitei EY, Parhar RS, Al-Mohanna FA, Shi Y.
Departments of Medicine (H.R., S.A.-s.), Genetics (R.A.-R., M.Z., E.Y.B., Y.S.), Pathology (H.A.-M.), and Biological and Medical Research (R.S.P., F.A.A.-M.), King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia.
Context: Dyshormonogenesis due to genetic defect in thyroglobulin (Tg) synthesis and secretion can lead to congenital hypothyroidism. Objectives: The aim of the study was to analyze the TG gene for the presence of mutations and to study the underlying mechanisms leading to dyshormonogenesis. Cases: Two siblings aged 25 and 31 yr presented with recurrent goitrous hypothyroidism with undetectable serum Tg. The older sibling was diagnosed with follicular variant of papillary thyroid carcinoma (FVPTC) at age 21 and metastatic FVPTC 8 yr later. Methods: The entire coding region of TG gene was sequenced. BRAF, RAS, and P53 mutations or PAX8/PPAR-gamma rearrangement were screened in the FVPTC. Tg expression was studied by immunohistochemistry. Results: Biallelic c.6725G>A (p.R2223H) and c.6396C>T (p.S2113L) sequence variations were detected in both patients and monoallelic variations in their family members. The c.6396C>T (p.S2113L) sequence variation was found in 14% of 100 population controls, whereas c.6725G>A variation was not present in the controls. Two previously reported polymorphisms (c.2200T>G and c.3082A>G) were present in all the family members. Strong cytoplasmic immunostaining of Tg was observed in the hyperplastic thyroid epithelial cells and weak or no staining in the follicular lumen. Cytoplasmic staining was localized in the endoplasmic reticulum. Reduced staining was found in the FVPTC. Neither RAS, BRAF, or P53 gene mutation nor a PAX8/PPAR-gamma rearrangement was detected in the tumor tissue. Conclusions: Biallelic c.6725G>A (p.R2223H) mutation causes Tg retention in the endoplasmic reticulum, resulting in dyshormonogenesis. Prolonged TSH stimulation may promote malignant transformation and development of thyroid cancer. The c.6396C>T (p.S2113L) is a novel polymorphism.

Cytological clues in the distinction between phyllodes tumor and fibroadenoma.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:16:00 +0000

Pubmed

Cytological clues in the distinction between phyllodes tumor and fibroadenoma.
El Hag IA, Aodah A, Kollur SM, Attallah A, Mohamed AA, Al-Hussaini H.
Department of Pathology, Riyadh Military Hospital, Riyadh, Saudi Arabia.
BACKGROUND:: Fine-needle aspiration (FNA) sensitivity in discriminating between phyllodes tumor and its benign mimicker fibroadenoma (FA) remains low. Because a preoperative categorization of phyllodes tumor is crucial for their appropriate management, the authors undertook this study in an effort to improve the outcome of FNA by identifying reliable distinguishing features. METHODS:: FNA smears from 15 and 12 histologically proven cases of phyllodes tumor and FA, respectively, were reviewed. The stromal and epithelial components were qualitatively and quantitatively analyzed. A group of cytological features that may distinguish between phyllodes tumor and FA were identified. Their value and reproducibility in categorizing phyllodes tumor cases were tested. RESULTS:: Three major cytological features were exclusively seen in all of, or the vast majority of, the phyllodes tumor cases; fibromyxoid stromal fragments with spindle nuclei (90%), fibroblastic pavements (93%), and appreciable number of spindles cells of fibroblastic nature among dispersed cell population (100%). The identification of these features improved the pick-up rate of phyllodes tumor from 40% to 100% and had substantial (kappa = 0.56-0.73) interobserver and almost perfect (kappa = 0.83) intraobserver reproducibility. There was no significant difference in the epithelial component characteristics between phyllodes tumor and FA. The frequency and degree of atypia in the dispersed cell population correlated well to the histological grade of phyllodes tumor. CONCLUSIONS:: FNA has proven to be a reliable test in differentiating between phyllodes tumor and FA with high sensitivity and good reproducibility. The importance of training and continuing education is emphasized. Cancer (Cancer Cytopathol) 2010. (c) 2010 American Cancer Society.

Status of hematopoietic stem cell transplantation in the WHO Eastern Mediterranean Region (EMRO)

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:15:00 +0000

Pubmed

Several centers are now performing allogeneic hematopoietic stem cell transplantation (HSCT) in the World Health Organization Eastern Mediterranean Region (EMRO) but the availability is still limited due to high cost and the need for multi-disciplinary team and an advanced laboratory support. Special issues including compatible donor availability, potential for alternate donor programs, differences in pattern of disease, pre-HSCT general status particularly for patients with BM failure, high sero-positivity for CMV, Hepatitis B and C infection and specific observations about GVHD with its relation to genetically homogeneous community are discussed. A total of 17 HSCT programs (performing five or more HSCTs annually) exist in nine countries of the EM region. Only six programs are currently reporting to EBMT or IBMTR. A total of 7617 HSCTs including 5701 allogeneic HSCTs have been performed. Due to low HSCT team density (1.5583 teams/10 million inhabitants versus 14.4333 in Europe) and very low HSCT team distribution (0.2729 teams/10,000sq km area versus <1 to 6 teams in Europe) only 70.8% of total population has access to such a program in EM region. GNI/capita had no clear association with low HSCT activity; however improvement in infrastructure and establishment of EM regional HSCT registry need prioritization. Copyright © 2010 Elsevier Ltd. All rights reserved.

Appropriateness of cancer pain management in Saudi teaching hospital

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:14:00 +0000

Pubmed

The aim of the study was to assess the appropriateness of pain management in cancer patients by determining the modalities of pain treatment currently provided to cancer patients, comparing this treatment to existing guideline on control of pain in patients with cancer and identifying areas of inappropriate prescribing. A prospective observational study was carried out in the oncology unit at tertiary-care teaching hospital in Riyadh, Saudi Arabia over a period from May-October 2006 included all adult cancer patients. Of 160 patients participated in the study, 80 (50%) reported moderate or severe pain. 40% of those with pain were not given any pain medication. Sixty percent of the patients had appropriate pain management. Pain documentation was inappropriate and needs improvement in 57% of the patients. There was under utilization of NSAIDs which were prescribed in 8 (5%) patients only from those on pain medication. Transdermal fentanyl was the most frequently used opioid (21%) for moderate to severe pain. Therefore, despite published guidelines for pain management, many patients with cancer receive inadequate analgesia.

Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil?

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:11:00 +0000

Pubmed

Inhibition of the repair of 5-fluorouracil (FU)-induced DNA lesions may improve the response of many tumors to this anticancer agent. Despite the identified associations between DNA strand breaks and the lethality of thymidylate synthase inhibitors, the role of DNA double-strand break (DSB) repair pathways in a cellular response to 5-FU treatment has not been studied yet. Isogenic cell lines defective (irs1SF), wild type (AA8), or reconstituted (1SFK8) in the DSB repair protein XRCC3 were used to investigate the effect of defective DSB repair on the overall sensitivity of cells to 5-FU and to see how targeting DSB repair may affect other cellular responses to 5-FU. Treatment with 5-FU resulted in (i) similar induction of DSB in both cell lines as indicated by the formation of gamma-H2AX (a marker for DSB). The repair of these breaks was complete in AA8 but not in irs1SF cells. (ii) Concentration-dependent reduction in the survival of both cell lines. The AA8 cells were six times more sensitive to 5-FU than the irs1SF cells. (iii) An earlier and more prolonged G1/S phase arrest in AA8 compared with the irs1SF cells. (iv) Induction of apoptosis as indicated by sub-G1 cells and caspase-3 activity in AA8 but not in irs1SF cells. XRCC3 complementation of irs1SF cells restored the wild-type phenotype. This result shows that targeting DSB repair is not always associated with increased sensitivity to DNA damaging agents such as 5-FU because it may affect other cellular responses such as cell cycle regulation and induction of apoptosis.

Renal cell cancer in Israel: Sex and ethnic differences in incidence and mortality, 1980-2004.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:09:00 +0000

Pubmed

Background: The causes of renal cell cancer (RCC) remain largely unexplained. While the incidence is generally higher in men than in women, little has been reported on ethnic differences. We examine trends in RCC incidence and mortality rates among Israeli Arab and Jewish populations and compared with the rates in other countries. Methods: Age-adjusted RCC incidence and mortality rates in Israel, during 1980-2004, were calculated by sex and population group, using the National Cancer Registry. They were compared with the United States based on the Surveillance Epidemiology and End Results [SEER] program and the IARC database for international comparisons. Results: While RCC incidence rates in Israel are similar to the United States and the European average, the rates are significantly higher among Israeli Jews than Arabs. Men are affected more than women. Incidence rates over the last 24 years have increased among all men and Jewish women, but not among Arab women. Among men, the incidence rate ratio for Jews to Arabs declined from 3.96 in 1980-1982 to 2.34 in 2001-2004, whereas for women there was no change. The mortality rates were higher among Jews than Arab and among men than women. There were no significant change in the mortality rates and rate ratios. Conclusions: Our findings demonstrate marked ethnic differences in RCC in Israel. The lower incidence among Arabs stands in contrast to the higher prevalence of potential risk factors for RCC in this population group. Genetic factors, diet and other lifestyle factors could play protective roles. Copyright © 2010 Elsevier Ltd. All rights reserved.

Outcome of children with Hodgkin's disease. A 10-year experience from a single institution in Kuwait

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:07:00 +0000

Pubmed

OBJECTIVE: To evaluate the outcome of children with Hodgkin's disease over a period of 10-years from a single institution in Kuwait. METHODS: Sixty-three children with previously untreated Hodgkin's disease, who were diagnosed at the Pediatric Oncology Unit of Kuwait Cancer Control Centre, Shuwaikh, Kuwait from January 1998 to December 2007 were included in the study. All cases were proved by histopathology, and staging was carried out according to the Ann Arbor system. RESULTS: Our series included 37 (59%) males and 26 (41%) females with a median age of 10 years (range 3-15 years). B symptoms were present in 20 (32%) children. Bulky disease was noted in 28 (44%) children, with stages III in 8 (13%) and IV in 12 (19%) children. Chemotherapy was administered as a primary treatment in 63 children. The median number of chemotherapy cycles given was 6 (range 2-8). Radiotherapy was used in 40 (63%) children. Grade III hematological toxicity was observed in 23 (37%) and grade IV in 14 (22%) children. Hypothyroidism was observed in 20 (32%) children. Fifty-five children achieved a complete remission (87%) and 2 children achieved a partial remission (3%) with an overall response rate of 90%. Three children achieved a progressive disease (5%) and response could not be evaluated in 3 (5%) children. At a median follow-up of 67 months (5.5 years), the overall survival was 91%. CONCLUSION: With moderate toxicity, combined modality therapy is effective in the treatment of childhood Hodgkin's disease.

Abscess of the abdominal wall resulting from perforated ascending colon cancer.

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:06:00 +0000

Pubmed

We report an unusual case of abscess of the abdominal wall as the initial symptom of a perforated right-sided colon cancer in a 62-year old man. Clinical examination revealed a non-fluctuating, tender, firm mass approximately 7 x 5 cm in diameter with overlying cellulitis in the right loin. Abdominal examination showed a fixed mass on the right side of the abdomen. Computed tomography (CT scan) confirmed the presence of a mass arising from the right colon with infiltration of the subcutaneous tissue by this intra-abdominal mass. Right hemicolectomy with lymph node dissection and en-bloc partial resection of the adherent parietal wall was performed and the final pathology showed a moderately differentiated mucinous adenocarcinoma. We report a case of ascending colon cancer presenting by an abscess of the abdominal wall.

The National Oncology Program: a Yemeni-Canadian partnership

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:04:00 +0000

Pubmed

Vandenberg T, Nagi N, Garcia B, Kirk C, Gilchrist J, Poirier S, Allen H, Driedger A, Fournie K, Basahi M, Robinsong M.
Department of Oncology, London Health Sciences Centre, Ontario, Canada. ted.vandenberg@lhsc.on.ca
Cancer in developing countries is growing and will soon be a major problem as life expectancy increases. This article outlines the experience and future objectives of a partnership between Yemeni and Canadian oncology professionals in their attempt to develop a National Oncology Program in Yemen. We review current knowledge of the epidemiology, social, educational and economic challenges as well as suggested initial steps in developing a relevant oncology program for this society.

Mammography Screening: Female Doctors'Attitudes and Practice in Sana'a, Yemen

noreply@blogger.com (Gulfoncology) — Sun, 14 Feb 2010 16:01:00 +0000

Pubmed

Mammography Screening: Female Doctors'Attitudes and Practice in Sana'a, Yemen.
Al-Naggar RA, Isa ZM, Shah SA, Chen R, Kadir YS.
Department of Medical Sciences, Faculty of Health and Life Sciences, Management and Science University (MSU), Malaysia Email: zms@ppukm.ukm.my.
A cross-sectional study was conducted at the main hospitals in Sana'a, Yemen to determine the attitude and practice of Yemen female doctors on mammography screening. Study subjects were all female doctors who were on duty during the questionnaire distribution. Those who agreed to participate were given the questionnaire to complete. Descriptive statistics were used to analyse socio-demographic variables and variables related to general health. Participants in this study were 105 female doctors with mean age of 32.1 years (SD = 7.17). Thirty-four respondents (36.6%) did not send asymptomatic women for mammography screening. The reasons were because of high cost (58.0%, n= 25), availability of other methods (23.3%, n= 10), instrument not available (11.6%, n= 5) and high risk of radiation (7.0%, n= 3). Twenty-five participants (26.9%) sent patients on regular basis if there was a family or personal history of breast cancer. Twenty-three participants (24.7%) sent the patients for mammogram screening every year regardless of the patients'history or symptoms. Although most doctors (36.5%) do not refer patients for mammography screening, seventy-seven (74.0%) indicated that they would refer patients for mammography screening on personal request by the patients. This study showed a low percentage of doctors who referred patients for routine mammography. The major reason given was the high cost of the procedure.

Symposium on Leukemia Update

noreply@blogger.com (Gulfoncology) — Wed, 27 Jan 2010 03:31:00 +0000

“Symposium on Leukemia Update”

Date: January 27, 2010

Venue: Saudi Aramco Oil Exhibition, Dhahran

Symposium Chairman : Dr. Ibrahim F. Al-Sheneber
Scientific Chairperson : Dr. Yusra Alawami

TIME
ACTIVITY
Wednesday, January 27th, 2010
8:00am - 9:00am
Registration
9:00am - 9:10am
Welcome Remarks / Introduction to SCF
Dr. Ibrahim F. Al-Sheneber
Session I – Moderator: Dr. Riyad Al-Daabil
09:10am - 09:30am
Epidemiology of Leukemia in KSA
Dr. Adil Al-Khatti, Saudi Aramco Hospital
09:30am - 09:50am
Molecular Biology & Bone Marrow Features of CML
Dr. Rehab Bu-Khamsin, Dammam Regional Lab
09:50am - 10:10am
CML Guidelines, and Challenges in Management of CML Patients in KSA
Dr. Yusra Al-Awami, Saudi Aramco Hospital
10:10am – 10:30am
Discussions
10:30am – 10:50am
Coffee Break
Session 2 – Moderator: Dr. Sharhabel Ammous
10:50am – 11:10am
Update in the Treatment of Pediatric ALL
Dr. Basil Abushullaih, Saudi Aramco Hospital
11:10am – 11:30am
Chronic Myeloid Leukemia with Pregnancy
Dr. Sahar Sunnari, Saudi Aramco Hospital
11:30am – 11:50am
Discussions
11:50am – 12:30pm
Prayer
Session 3 – Moderator: Dr. Yusra Al-Awami
12:30pm – 12:50pm
ASH 2009:Emerging Data in the Management of CML
Dr. Ahmed Al-Sagheer, KFSHD
12:50pm – 01:10pm
CML Therapy with TKIs: What is the end point?
Dr. Philipp Le Coutre, France
01:10pm – 01:30pm
Discussions & Closing
01:30pm – 01:50pm
Award Ceremony Followed By Lunch

Lymph node yield in rectal cancer surgery: Effect of preoperative chemoradiotherapy

noreply@blogger.com (Gulfoncology) — Sat, 16 Jan 2010 17:29:00 +0000

Pubmed

Morcos B, Baker B, Al Masri M, Haddad H, Hashem S.
Department of Surgery and Surgical Oncology, King Hussein Cancer Center, Amman, Jordan.
AIM: Adequate lymph node resection in rectal cancer is important for staging and local control. This study aims to verify the effect of neoadjuvant chemoradiation, as well as some clinicopathological features, on the yield of lymph nodes in rectal carcinoma. METHODS: Data on consecutive patients who had total mesorectal excision for rectal adenocarcinoma at a single cancer center between January 2003 and July 2008 were reviewed. No patient had any prior pelvic surgery or radiotherapy. Patients had neoadjuvant chemoradiotherapy if they were stage II or III. RESULTS: A total of 116 patients were included. The mean age was 53 years (range 29-83). Fifty-nine patients (51%) received neoadjuvant therapy before resection. The mean number of lymph nodes removed was 18 (range 4-67) per specimen. There was less lymph node yield in patients who received neoadjuvant therapy (16 vs. 19, p = 0.008). Only 64% of patients who had preoperative therapy had 12 lymph nodes or more in the specimen as opposed to 88% of those who had surgery upfront (p = 0.003). Other factors associated with lower lymph node yield included: female sex (p = 0.03) and tumour location in the lower rectum (p = 0.002). Age, tumour stage and grade, type of operation and surgical delay did not affect the number of lymph nodes removed. CONCLUSION: Preoperative chemoradiotherapy for rectal cancer results in reduction in lymph node yield. Female sex and lower rectal tumours are also associated with retrieval of fewer lymph nodes. Copyright © 2009 Elsevier Ltd. All rights reserved.

Attitudes Toward Children With Clefts in Rural Muslim and Hindu Societies

noreply@blogger.com (Gulfoncology) — Sat, 16 Jan 2010 17:27:00 +0000

Pubmed

El-Shazly M, Bakry R, Tohamy A, Ali WM, Elbakry S, Brown SE, Weatherley-White RC.
From the *Department of Plastic Surgery, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; daggerOperation Smile Egypt, Cairo, Egypt; double daggerOncological Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; section signDepartment of Psychiatry, Banha University, Banha, Egypt; paragraph signDepartment of Anthropology, University ofConnecticut, Storrs, CT; and ||Operation Smile Inc, Norfolk, VA.
Many charitable organizations conduct overseas missions to correct cleft lip and palate where surgical care is hard to obtain. However, little is known about genetic backgrounds, cultural and societal attitudes regarding the cleft deformity. A questionnaire has been designed to elicit these attitudes.The questionnaire was administered to 50 families of children with cleft lip seeking care at Operation Smile missions in each of 2 disparate rural communities, one in the state of Gujarat in India and the other in the upper Nile valley in Egypt.Saliva and blood samples were collected from all patients to investigate MSX1, IRF6, PVRL1, MHC class I chain related (MICA), TP73L, MTHFR, TGF-beta3, and RAR alpha genes, within a proposed multinational genetic research project for cleft causation using micro-array and polymerase chain reaction (PCR) methods. All patients had been operated and experienced good results through the follow-up period, which was ranging from 3-24 months.Demographic data defined literacy and educational level; answers established the degree of social isolation, the impact on the family, and the expectations of what surgery would accomplish for the child. Beliefs concerning the causation of the cleft were explored in detail.Knowledge of these issues is important for the more complete care of children in an unfamiliar cultural environment.

Prevalence of Candida dubliniensis among cancer patients in Kuwait: a 5-year retrospective study.

noreply@blogger.com (Gulfoncology) — Sat, 16 Jan 2010 04:46:00 +0000

Pubmed

Mokaddas E, Khan ZU, Ahmad S.
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Despite close genetic and phenotypic relationship of Candida dubliniensis with Candida albicans, its role in human disease is mostly restricted to oral colonisation, particularly among HIV-infected patients. The prevalence of C. dubliniensis in association with other disease conditions has been infrequently reported. In this study, we present data on the prevalence of C. dubliniensis among yeast species isolated from cancer patients over a 5-year period. A total of 1445 yeast isolates recovered from respiratory specimens, blood, urine and oral swabs were analysed. Candida dubliniensis isolates were provisionally identified by phenotypic methods and their identity was further confirmed by species-specific amplification and/or sequencing of internally transcribed spacer region of rDNA. Antifungal susceptibility for fluconazole was determined by Etest. The number of isolates identified as C. dubliniensis, C. albicans and other yeast species were 71 (4.9%), 862 (59.6%) and 512 (35%) respectively. All the C. dubliniensis isolates originated from respiratory (5.9%) or oral (3.2%) specimens with an overall prevalence of 4.9%, and were found to be susceptible to fluconazole. The isolation of C. dubliniensis from respiratory or oral specimens and not from blood or urine specimens suggests that this species has preference to colonise these sites of human body.

Symposium on Leukemia Update

noreply@blogger.com (Gulfoncology) — Sat, 16 Jan 2010 04:39:00 +0000

“Symposium on Leukemia Update”
Date: January 27, 2010
Venue: Saudi Aramco Oil Exhibition, Dhahran

Symposium Chairman : Dr. Ibrahim F. Al-Sheneber
Scientific Chairperson : Dr. Yusra Alawami

TIME
ACTIVITY
Wednesday, January 27th, 2010
8:00am - 9:00am
Registration
9:00am - 9:10am
Welcome Remarks / Introduction to SCF
Dr. Ibrahim F. Al-Sheneber
Session I – Moderator: Dr. Riyad Al-Daabil
09:10am - 09:30am
Epidemiology of Leukemia in KSA
Dr. Adil Al-Khatti, Saudi Aramco Hospital
09:30am - 09:50am
Molecular Biology & Bone Marrow Features of CML
Dr. Rehab Bu-Khamsin, Dammam Regional Lab
09:50am - 10:10am
CML Guidelines, and Challenges in Management of CML Patients in KSA
Dr. Yusra Al-Awami, Saudi Aramco Hospital
10:10am – 10:30am
Discussions
10:30am – 10:50am
Coffee Break
Session 2 – Moderator: Dr. Sharhabel Ammous
10:50am – 11:10am
Update in the Treatment of Pediatric ALL
Dr. Basil Abushullaih, Saudi Aramco Hospital
11:10am – 11:30am
Chronic Myeloid Leukemia with Pregnancy
Dr. Sahar Sunnari, Saudi Aramco Hospital
11:30am – 11:50am
Discussions
11:50am – 12:30pm
Prayer
Session 3 – Moderator: Dr. Yusra Al-Awami
12:30pm – 12:50pm
ASH 2009:Emerging Data in the Management of CML
Dr. Ahmed Al-Sagheer, KFSHD
12:50pm – 01:10pm
CML Therapy with TKIs: What is the end point?
Dr. Philipp Le Coutre, France
01:10pm – 01:30pm
Discussions & Closing
01:30pm – 01:50pm
Award Ceremony Followed By Lunch

Prevalence of Candida dubliniensis among cancer patients in Kuwait: a 5-year retrospective study

noreply@blogger.com (Gulfoncology) — Mon, 11 Jan 2010 03:14:00 +0000

Pubmed

Despite close genetic and phenotypic relationship of Candida dubliniensis with Candida albicans, its role in human disease is mostly restricted to oral colonisation, particularly among HIV-infected patients. The prevalence of C. dubliniensis in association with other disease conditions has been infrequently reported. In this study, we present data on the prevalence of C. dubliniensis among yeast species isolated from cancer patients over a 5-year period. A total of 1445 yeast isolates recovered from respiratory specimens, blood, urine and oral swabs were analysed. Candida dubliniensis isolates were provisionally identified by phenotypic methods and their identity was further confirmed by species-specific amplification and/or sequencing of internally transcribed spacer region of rDNA. Antifungal susceptibility for fluconazole was determined by Etest. The number of isolates identified as C. dubliniensis, C. albicans and other yeast species were 71 (4.9%), 862 (59.6%) and 512 (35%) respectively. All the C. dubliniensis isolates originated from respiratory (5.9%) or oral (3.2%) specimens with an overall prevalence of 4.9%, and were found to be susceptible to fluconazole. The isolation of C. dubliniensis from respiratory or oral specimens and not from blood or urine specimens suggests that this species has preference to colonise these sites of human body.

Breast Cancer Awareness Campaign

noreply@blogger.com (Gulfoncology) — Sat, 09 Jan 2010 04:06:00 +0000

Saudi Gazette - Prince Alwaleed Bin Talal Bin Abdul Aziz, Chairman of the Board of Trustees of Alwaleed Bin Talal Foundation, has donated SR500,000 to support the second phase of the breast cancer awareness campaign.

The campaign is aimed at raising national awareness to fight breast cancer and early detection through self examination, medical checkups and focusing on the importance of regular mammogram screening.

The Zahra Breast Cancer Association, headed by Princess Haifa Bint Faisal Bin Abdul Aziz strives to implement awareness programs on this issue.

Moreover, the society carries out a comprehensive survey across the Kingdom and encourages qualified Saudi nationals in the areas of breast cancer research through training programs, education and scholarships for further research in this area.

Urban-rural differences of gynaecological malignancies in Egypt (1999-2002

noreply@blogger.com (Gulfoncology) — Sun, 03 Jan 2010 23:10:00 +0000

Pubmed

Dey S, Hablas A, Seifeldin IA, Ismail K, Ramadan M, El-Hamzawy H, Wilson ML, Banerjee M, Boffetta P, Harford J, Merajver SD, Soliman AS.
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Objective In previous studies, we have shown a three to four times higher urban incidence of breast cancer and estrogen receptor-positive breast cancers in the Gharbiah Province of Egypt. We investigated the urban-rural incidence differences of gynaecologic malignancies (uterine, ovarian and cervical cancers) to explore if they show the same trend that we found for breast cancer. Design Cancer registry-based incidence comparison. Setting Gharbiah population-based cancer registry (GPCR), Tanta, Egypt. Sample All patients with uterine, ovarian and cervical cancer in GPCR from 1999 to 2002. Methods We calculated uterine, ovarian and cervical cancer incidence from 1999 to 2002. For each of the three cancers, we calculated the overall and age-specific rates for the province as a whole, and by urban-rural status, as well as for the eight districts of the province. Results Incidence of all three cancer sites was higher in urban than in rural areas. Uterine cancer showed the highest urban-rural incidence rate ratio (IRR = 6.07, 95% CI = 4.17, 8.85). Uterine cancer also showed the highest urban incidence in the oldest age group (70+ age category, IRR = 14.39, 95% CI = 4.24, 48.87) and in developed districts (Tanta, IRR = 4.14, 95% CI = 0.41, 42.04). Incidence rates by groups of cancer sites showed an increasing gradient of urban incidence for cancers related to hormonal aetiology, mainly of the breast and uterus (IRR = 4.96, 95% CI = 2.86, 8.61). Conclusions The higher urban incidence of uterine cancer, coupled with our previous findings of higher incidence of breast cancer and estrogen receptor positive breast cancer in urban areas in this region, may be suggestive of possible higher exposure to environmental estrogenic compounds, such as xenoestrogens, in urban areas.